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AbNano® Single
Domain Antibody
Libraries

AbNano® Single Domain Antibody Libraries

Library architecture shapes binder diversity, screening efficiency, and the range of epitopes accessible during discovery. When programs involve structurally complex targets, multispecific design requirements, or constrained development timelines, repertoire selection becomes a critical technical variable.

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Single Domain Antibodies Solve Challenges Conventional Antibodies Cannot

AbNano VHHs are single-domain antigen-binding regions derived from camelid heavy-chain antibodies. Their compact size, extended CDR3 architecture, and biochemical stability make them valuable in discovery settings where conventional antibody formats may face structural or engineering constraints.

Use VHH libraries when programs require:

Access to recessed, cryptic, conformational, or sterically constrained epitopes
Modular assembly into bispecific, trispecific, and multispecific constructs
Compatibility with CAR-T and CAR-NK targeting architectures
Reliable folding and expression across host systems
Stable performance in demanding assay or buffer environments
Efficient progression into engineering and humanization workflows

Multiple Paths to Qualified Binders

VHHs are single-domain antigen-binding regions derived from camelid heavy-chain antibodies. Their compact size, extended CDR3 architecture, and biochemical stability make them valuable in discovery settings where conventional antibody formats may face structural or engineering constraints.

Multiple Paths To Qualified Binders Phage Display Discovery Workflows

Phage display enables iterative enrichment of target-reactive clones from diverse repertoires, supporting efficient binder discovery across complex target classes. Programs may include target strategy, panning, clone screening, sequencing, hit triage, recombinant conversion, and progression into advanced molecular formats.

Custom Library Development

Programs requiring a differentiated starting point may pursue custom library development aligned to proprietary biology, novel modalities, target classes, or internal platform requirements.

Fortis Discovery Services

Fortis scientific teams can extend internal capacity with support across screening strategy, execution, sequence analysis, candidate prioritization, and downstream progression workflows.

Start with the Right Repertoire

The right starting strategy can improve hit quality, expand accessible target space, and reduce downstream rework. Explore available libraries or connect with our scientific team to discuss fit.